Di-T-butyl dicarbonate immediately delivery 24424-99-5 good supplier competitive price 24424-99-5 CAS NO.24424-99-5

Reagent for the introduction of the Boc protecting group.Di-tert-butyl dicarbonate is a reagent used for the introduction of BOC protecting group. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.

Boc-anhydride is widely used for the introduction of the acid-labile Boc-protecting group in organic synthesis. It is extensively used for the protection of amino groups in the synthesis of amino acids, alkaloids, and peptides. Boc-anhydride reacts rapidly and cleanly with the only by-products being carbon dioxide and t-butanol. It is an efficient tert-butoxycarbonylating agent for alcohols and thiols. This group is easily removed by thermolysis or under moderately acidic conditions, such as, treatment with TFA. The Boc protecting group strategy is the preferred method of choice due to its: easy installation, removal, stability towards nucleophiles, and strong basic conditions. In the presence of moisture, it decomposes into tert-butanol and CO₂.